Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils.Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause Congenital Contractural Arachnodactyly.Both are autosomal dominant disorders, and both disorders affect

Snoring and obstructive sleep apnoea (OSA) are increasingly common conditions, and confer a significant health and socioeconomic burden.Furthermore, untreated OSA represents a significant mortality risk.Patients require careful assessment, including detailed clinical history and examination, sleep study and drug-induced sleep endoscopy (DISE).Altho

Abstract Background A congenital prepubic sinus Skin Care Tools (CPS) is a rare congenital anomaly in which a duct remnant extends from the skin opening near the pubic symphysis to various parts and the lesions are mostly located in the preperitoneal space.The totally extraperitoneal (TEP) approach is an operational method that provides a good fiel

Victorious ending of the World War 2 on May, 9, 1945, stroke a crushing Time Release Dispensers blow on the military axis Berlin - Rome - Tokyo.The USSR played a decisive role both on European and Asian fronts.Fulfilling its allied duty the Soviet Union entered the war in the Far East on 9 August, 1945 and defeated the Japanese army in Manchuria.Th